Ontology highlight
ABSTRACT:
SUBMITTER: Marrone AK
PROVIDER: S-EPMC4073423 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Marrone April K AK Stolz Donna B DB Bastacky Sheldon I SI Kostka Dennis D Bodnar Andrew J AJ Ho Jacqueline J
Journal of the American Society of Nephrology : JASN 20140207 7
Deletion of all microRNAs (miRNAs) in nephron progenitors leads to premature loss of these cells, but the roles of specific miRNAs in progenitors have not been identified. Deletions in the MIR17HG cluster (miR-17~92 in mice), detected in a subset of patients with Feingold syndrome, represent the first miRNA mutations to be associated with a developmental defect in humans. Although MIR17HG is expressed in the developing kidney, and patients with Feingold syndrome caused by MYCN mutations have ren ...[more]