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Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.

ABSTRACT: Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.

SUBMITTER: Shin Y

PROVIDER: S-EPMC4074172 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.

Shin Yoojin Y Kim Hyunju H Han Sewoon S Won Jihee J Jeong Hyo Eun HE Lee Eun-Sook ES Kamm Roger D RD Kim Jae-Hong JH Chung Seok S

Advanced healthcare materials 20121126 6

Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs. ...[more]

PMID: 23184641

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