Ontology highlight
ABSTRACT:
SUBMITTER: Wohrer S
PROVIDER: S-EPMC4074342 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wohrer Stefan S Knapp David J H F DJ Copley Michael R MR Benz Claudia C Kent David G DG Rowe Keegan K Babovic Sonja S Mader Heidi H Oostendorp Robert A J RA Eaves Connie J CJ
Cell reports 20140606 6
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur in vivo, but molecularly defined conditions that support similar responses in vitro are lacking. We hypothesized that this might require a combination of factors that differentially promote HSC viabili ...[more]