Ontology highlight
ABSTRACT:
SUBMITTER: Perea G
PROVIDER: S-EPMC4075037 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Perea Gertrudis G Yang Aimei A Boyden Edward S ES Sur Mriganka M
Nature communications 20140101
Astrocytes play important roles in synaptic transmission and plasticity. Despite in vitro evidence, their causal contribution to cortical network activity and sensory information processing in vivo remains unresolved. Here we report that selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate receptors. Photostimulation of astrocytes in vivo in ...[more]