Ontology highlight
ABSTRACT:
SUBMITTER: Teterina NL
PROVIDER: S-EPMC4075184 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Teterina Natalya L NL Liu Guangping G Maximova Olga A OA Pletnev Alexander G AG
Virology 20140419
In recent years, microRNA-targeting has become an effective strategy for selective control of tissue-tropism and pathogenesis of both DNA and RNA viruses. Here, using a neurotropic flavivirus as a model, we demonstrate that simultaneous miRNA targeting of the viral genome in the open reading frame and 3'-noncoding regions for brain-expressed miRNAs had an additive effect and produced a more potent attenuation of the virus compared to separate targeting of those regions. Multiple miRNA co-targeti ...[more]