Ontology highlight
ABSTRACT:
SUBMITTER: Biggs LC
PROVIDER: S-EPMC4075356 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Biggs Leah C LC Naridze Rachelle L RL DeMali Kris A KA Lusche Daniel F DF Kuhl Spencer S Soll David R DR Schutte Brian C BC Dunnwald Martine M
Journal of cell science 20140428 Pt 13
Interferon regulatory factor 6 (Irf6) regulates keratinocyte proliferation and differentiation. In this study, we tested the hypothesis that Irf6 regulates cellular migration and adhesion. Irf6-deficient embryos at 10.5 days post-conception failed to close their wound compared with wild-type embryos. In vitro, Irf6-deficient murine embryonic keratinocytes were delayed in closing a scratch wound. Live imaging of the scratch showed deficient directional migration and reduced speed in cells lacking ...[more]