Ontology highlight
ABSTRACT:
SUBMITTER: Wang LL
PROVIDER: S-EPMC5451405 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wang Lu-Lu LL Chen Zheng-Sen ZS Zhou Wen-Di WD Shu Jin J Wang Xiao-Hua XH Jin Rui R Zhuang Li-Li LL Hoda Mir Alireza MA Zhang Hao H Zhou Guo-Ping GP
Scientific reports 20170531 1
Interferon regulatory factor 3 (IRF-3) is widely known for its prompt response against viral infection by activating the interferon system. We previously reported that E2F1, Sp1 and Sp3 regulated transcriptional activity of IRF-3. Recently, different expression patterns of IRF-3 were found in lung cancer, leading to the alternation of the immunomodulatory function in tumorigenesis. However, the mechanism of transcriptional regulation of IRF-3 in lung cancer has not been extensively studied. Here ...[more]