Ontology highlight
ABSTRACT:
SUBMITTER: Cekanaviciute E
PROVIDER: S-EPMC4075480 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cekanaviciute Egle E Dietrich Hans K HK Axtell Robert C RC Williams Aaron M AM Egusquiza Riann R Wai Karen M KM Koshy Anita A AA Buckwalter Marion S MS
Journal of immunology (Baltimore, Md. : 1950) 20140523 1
The balance between controlling infection and limiting inflammation is particularly precarious in the brain because of its unique vulnerability to the toxic effects of inflammation. Astrocytes have been implicated as key regulators of neuroinflammation in CNS infections, including infection with Toxoplasma gondii, a protozoan parasite that naturally establishes a chronic CNS infection in mice and humans. In CNS toxoplasmosis, astrocytes are critical to controlling parasite growth. They secrete p ...[more]