Ontology highlight
ABSTRACT:
SUBMITTER: Waidmann O
PROVIDER: S-EPMC7530720 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Waidmann Oliver O Pleli Thomas T Weigert Andreas A Imelmann Esther E Kakoschky Bianca B Schmithals Christian C Döring Claudia C Frank Matthias M Longerich Thomas T Köberle Verena V Hansmann Martin-Leo ML Brüne Bernhard B Zeuzem Stefan S Piiper Albrecht A Dikic Ivan I
Scientific reports 20201001 1
The nuclear factor kappa beta (NFκB) signaling pathway plays an important role in liver homeostasis and cancer development. Tax1-binding protein 1 (Tax1BP1) is a regulator of the NFκB signaling pathway, but its role in the liver and hepatocellular carcinoma (HCC) is presently unknown. Here we investigated the role of Tax1BP1 in liver cells and murine models of HCC and liver fibrosis. We applied the diethylnitrosamine (DEN) model of experimental hepatocarcinogenesis in Tax1BP1<sup>+/+</sup> and T ...[more]