Ontology highlight
ABSTRACT:
SUBMITTER: Wang QA
PROVIDER: S-EPMC4075943 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wang Qiong A QA Tao Caroline C Gupta Rana K RK Scherer Philipp E PE
Nature medicine 20130901 10
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy ...[more]