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Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts.

ABSTRACT: A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA.

SUBMITTER: Ichiishi N

PROVIDER: S-EPMC4076000 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts.

Ichiishi Naoko N Brooks Allen F AF Topczewski Joseph J JJ Rodnick Melissa E ME Sanford Melanie S MS Scott Peter J H PJ

Organic letters 20140603 12

A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA. ...[more]

PMID: 24890658

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