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Pd-catalyzed nucleophilic fluorination of aryl bromides.

ABSTRACT: On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.

SUBMITTER: Lee HG

PROVIDER: S-EPMC3954505 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Pd-catalyzed nucleophilic fluorination of aryl bromides.

Lee Hong Geun HG Milner Phillip J PJ Buchwald Stephen L SL

Journal of the American Chemical Society 20140227 10

On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction. ...[more]

PMID: 24559304

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