Pd-catalyzed nucleophilic fluorination of aryl bromides.
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ABSTRACT: On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
SUBMITTER: Lee HG
PROVIDER: S-EPMC3954505 | biostudies-literature |
REPOSITORIES: biostudies-literature
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