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Au nanomatryoshkas as efficient near-infrared photothermal transducers for cancer treatment: benchmarking against nanoshells.

ABSTRACT: Au nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of this process is nanoparticle size, which influences both tumor uptake and photothermal efficiency. Here, we report a direct comparative study of ?90 nm diameter Au nanomatryoshkas (Au/SiO2/Au) and ?150 nm diameter Au nanoshells for photothermal therapeutic efficacy in highly aggressive triple negative breast cancer (TNBC) tumors in mice. Au nanomatryoshkas are strong light absorbers with 77% absorption efficiency, while the nanoshells are weaker absorbers with only 15% absorption efficiency. After an intravenous injection of Au nanomatryoshkas followed by a single NIR laser dose of 2 W/cm(2) for 5 min, 83% of the TNBC tumor-bearing mice appeared healthy and tumor free >60 days later, while only 33% of mice treated with nanoshells survived the same period. The smaller size and larger absorption cross section of Au nanomatryoshkas combine to make this nanoparticle more effective than Au nanoshells for photothermal cancer therapy.

SUBMITTER: Ayala-Orozco C

PROVIDER: S-EPMC4076033 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Au nanomatryoshkas as efficient near-infrared photothermal transducers for cancer treatment: benchmarking against nanoshells.

Ayala-Orozco Ciceron C Urban Cordula C Knight Mark W MW Urban Alexander Skyrme AS Neumann Oara O Bishnoi Sandra W SW Mukherjee Shaunak S Goodman Amanda M AM Charron Heather H Mitchell Tamika T Shea Martin M Roy Ronita R Nanda Sarmistha S Schiff Rachel R Halas Naomi J NJ Joshi Amit A

ACS nano 20140603 6

Au nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of this process is nanoparticle size, which influences both tumor uptake and photothermal efficiency. Here, we report a direct comparative study of ∼90 nm diameter Au nanomatryoshkas (Au/SiO2/Au) and ∼150 nm diameter Au nanoshells fo ...[more]

PMID: 24889266

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Project description:Investigation of targeting inhibitors of A? aggregation, heme-A? peroxidase-like activity and efficient detectors of A? aggregation, are of therapeutic value and diagnostics significance for the treatment of Alzheimer's disease (AD). Due to the complex pathogenesis of AD, theranostics treatment with multiple functions are necessary. Herein we constructed the NIR absorption property of gold nanorods (GNRs) loaded with single chain variable fragment (scFv) 12B4 and thermophilic acylpeptide hydrolase (APH) ST0779 as a smart theranostic complex (GNRs-APH-scFv, GAS), which possesses both rapid detection of A? aggregates and NIR photothermal treatment that effectively disassembles A? aggregates and inhibits A?-mediated toxicity. Methods: We screened targeting anti-A? scFv 12B4 and thermophilic acylpeptide hydrolase as amyloid-degrading enzyme, synthesized GAS gold nanorods complex. The GAS was evalued by A? inhibition and disaggregation assays, A? detection assays, A? mediated toxicity assays in vitro. In vivo, delaying A?-induced paralysis in AD model of Caenorhabditis elegans was also tested by GAS. Results: In vitro, GAS has a synergistic effect to inhibit and disassociate A? aggregates, in addition to decrease heme-A? peroxidase-like activity. In cultured cells, treatment with GAS reduces A?-induced cytotoxicity, while also delaying A?-mediated paralysis in CL4176 C.elegans model of AD. Furthermore, the photothermal effect of the GAS upon NIR laser irradiation not only helps disassociate the A? aggregates but also boosts APH activity to clear A?. The GAS, as a targeting detector and inhibitor, allows real-time detection of A? aggregates. Conclusion: These results firstly highlight the combination of scFv, APH and nanoparticles to be theranostic AD drugs. Taken together, our strategy provides a new thought into the design of smart compounds for use as efficiently therapeutic and preventive agents against AD. Moreover, our design provides broad prospects of biomedical strategy for further theranostics application in those diseases caused by abnormal protein.

Dataset Information

Au nanomatryoshkas as efficient near-infrared photothermal transducers for cancer treatment: benchmarking against nanoshells.

Publications

Au nanomatryoshkas as efficient near-infrared photothermal transducers for cancer treatment: benchmarking against nanoshells.

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