Ontology highlight
ABSTRACT:
SUBMITTER: Reznik B
PROVIDER: S-EPMC4076271 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Reznik Boris B Clement Sandra L SL Lykke-Andersen Jens J
PloS one 20140630 6
The tristetraprolin (TTP) family of zinc-finger proteins, TTP, BRF1 and BRF2, regulate the stability of a subset of mRNAs containing 3'UTR AU-rich elements (AREs), including mRNAs coding for cytokines, transcription factors, and proto-oncogenes. To better understand the mechanism by which TTP-family proteins control mRNA stability in mammalian cells, we aimed to identify TTP- and BRF1-interacting proteins as potential TTP-family co-factors. This revealed hnRNP F as a prominent interactor of TTP ...[more]