Ontology highlight
ABSTRACT:
SUBMITTER: Kratochvill F
PROVIDER: S-EPMC3737733 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Kratochvill Franz F Machacek Christian C Vogl Claus C Ebner Florian F Sedlyarov Vitaly V Gruber Andreas R AR Hartweger Harald H Vielnascher Raimund R Karaghiosoff Marina M Rülicke Thomas T Müller Mathias M Hofacker Ivo I Lang Roland R Kovarik Pavel P
Molecular systems biology 20111220
For a successful yet controlled immune response, cells need to specifically destabilize inflammatory mRNAs but prevent premature removal of those still used. The regulatory circuits controlling quality and timing in the global inflammatory mRNA decay are not understood. Here, we show that the mRNA-destabilizing function of the AU-rich element-binding protein tristetraprolin (TTP) is inversely regulated by the p38 MAPK activity profile such that after inflammatory stimulus the TTP-dependent decay ...[more]