Regulation of ferroptotic cancer cell death by GPX4.
Ontology highlight
ABSTRACT:
SUBMITTER: Yang WS
PROVIDER: S-EPMC4076414 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Regulation of ferroptotic cancer cell death by GPX4.
Yang Wan Seok WS SriRamaratnam Rohitha R Welsch Matthew E ME Shimada Kenichi K Skouta Rachid R Viswanathan Vasanthi S VS Cheah Jaime H JH Clemons Paul A PA Shamji Alykhan F AF Clish Clary B CB Brown Lewis M LM Girotti Albert W AW Cornish Virginia W VW Schreiber Stuart L SL Stockwell Brent R BR
Cell 20140101 1-2
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds and a chemoproteomics strategy to discover that GPX4 is directly inhibited by a second class of compounds. GPX4 overexpression and knockdown modula ...[more]
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