HSPB1 as a novel regulator of ferroptotic cancer cell death.
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ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC4640181 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
HSPB1 as a novel regulator of ferroptotic cancer cell death.
Sun X X Ou Z Z Xie M M Kang R R Fan Y Y Niu X X Wang H H Cao L L Tang D D
Oncogene 20150302 45
Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inh ...[more]
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