Evaluation of coding-independent functions of the transcribed bovine aromatase pseudogene CYP19P1.

ABSTRACT:

Background

CYP19A1 encodes the aromatase which catalyzes the final reaction of estrogen biosynthesis. The bovine genome also contains a non-coding copy of CYP19A1, the transcribed pseudogene CYP19P1. Whereas CYP19A1 is transcribed in all estrogen-producing tissues, mainly in the placenta and gonads, the CYP19P1 transcript so far was detected in the placenta. Strikingly, one sequence segment of both transcripts exhibits an exceptional high identity of 98%, which implies selective pressure and suggests some kind of function. Only recently, indeed, coding-independent functions of several transcribed pseudogenes were reported. Therefore, we analyzed CYP19P1 and CYP19A1 transcripts with the aim to detect clues for gene-pseudogene interference.

Findings

The CYP19P1 transcript was

SUBMITTER: Chwalisz M 

PROVIDER: S-EPMC4076500 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature