Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira-Mateos C
PROVIDER: S-EPMC6726650 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Oliveira-Mateos Cristina C Sánchez-Castillo Anaís A Soler Marta M Obiols-Guardia Aida A Piñeyro David D Boque-Sastre Raquel R Calleja-Cervantes Maria E ME Castro de Moura Manuel M Martínez-Cardús Anna A Rubio Teresa T Pelletier Joffrey J Martínez-Iniesta Maria M Herrero-Martín David D Tirado Oscar M OM Gentilella Antonio A Villanueva Alberto A Esteller Manel M Farré Lourdes L Guil Sonia S
Nature communications 20190904 1
One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseudogene RPSAP52. RPSAP52 is abundantly present in the cytoplasm, where it interacts with the RNA binding protein IGF2BP2/IMP2, facilitating its binding to mRNA targets, promoting their translation by me ...[more]