Ontology highlight
ABSTRACT:
SUBMITTER: Shamsipour F
PROVIDER: S-EPMC4076657 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Shamsipour Fereshteh F Hosseinzadeh Saeeideh S Arab Seyed Shahriar SS Vafaei Sedigheh S Farid Samira S Jeddi-Tehrani Mahmood M Balalaie Saeed S
Journal of chemical biology 20140518 3
Hesperadin is one of the indolinones that was designed against the ATP-binding site of Aurora kinase. This molecule inhibits Aurora B kinase by phosphorylation of histone H3. In this study, new derivatives of Hesperadin containing an amide group in their structures were synthesized through sequential Ugi/palladium-catalyzed approach and in vitro antitumor activity of new compounds were evaluated by cell proliferation assay. The results show that compounds 6f, 6i, 6l, and 6o were dose-dependently ...[more]