Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.
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ABSTRACT:
SUBMITTER: Shen B
PROVIDER: S-EPMC4077287 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.
Shen Bin B Jeon Jongho J Palner Mikael M Ye Deju D Shuhendler Adam A Chin Frederick T FT Rao Jianghong J
Angewandte Chemie (International ed. in English) 20130723 40
Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture). ...[more]
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