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Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.

ABSTRACT: Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

SUBMITTER: Shen B 

PROVIDER: S-EPMC4077287 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.

Shen Bin B   Jeon Jongho J   Palner Mikael M   Ye Deju D   Shuhendler Adam A   Chin Frederick T FT   Rao Jianghong J  

Angewandte Chemie (International ed. in English) 20130723 40

Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture). ...[more]

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