Mechanisms of functional promiscuity by HP1 proteins.
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ABSTRACT:
SUBMITTER: Canzio D
PROVIDER: S-EPMC4077871 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Mechanisms of functional promiscuity by HP1 proteins.
Canzio Daniele D Larson Adam A Narlikar Geeta J GJ
Trends in cell biology 20140304 6
Heterochromatin protein 1 (HP1) proteins were originally identified as critical components in heterochromatin-mediated gene silencing and are now recognized to play essential roles in several other processes including gene activation. Several eukaryotes possess more than one HP1 paralog. Despite high sequence conservation, the HP1 paralogs achieve diverse functions. Further, in many cases, the same HP1 paralog is implicated in multiple functions. Recent biochemical studies have revealed interest ...[more]
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