Ontology highlight
ABSTRACT:
SUBMITTER: Larson AR
PROVIDER: S-EPMC4077910 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Larson Allison R AR Dresser Karen A KA Zhan Qian Q Lezcano Cecilia C Woda Bruce A BA Yosufi Benafsha B Thompson John F JF Scolyer Richard A RA Mihm Martin C MC Shi Yujiang G YG Murphy George F GF Lian Christine Guo CG
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20140103 7
DNA methylation is the most well-studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We recently reported the loss of 5-hydroxymethylcytosine in melanoma compared with benign nevi and suggested that loss of this epigenetic marker is correlated with tumor virulence based on its association with a worse prognosis. In this study, we further characterize the immunorea ...[more]