Ontology highlight
ABSTRACT:
SUBMITTER: Gleghorn ML
PROVIDER: S-EPMC4077987 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Gleghorn Michael L ML Maquat Lynne E LE
Trends in biochemical sciences 20140619 7
The canonical double-stranded RNA (dsRNA)-binding domain (dsRBD) is composed of an α1-β1-β2-β3-α2 secondary structure that folds in three dimensions to recognize dsRNA. Recently, structural and functional studies of divergent dsRBDs revealed adaptations that include intra- and/or intermolecular protein interactions, sometimes in the absence of detectable dsRNA-binding ability. We describe here how discrete dsRBD components can accommodate pronounced amino-acid sequence changes while maintaining ...[more]