Ontology highlight
ABSTRACT:
SUBMITTER: Poulsen H
PROVIDER: S-EPMC1484439 | biostudies-other | 2006 Jul
REPOSITORIES: biostudies-other
Poulsen Hanne H Jorgensen Rasmus R Heding Anders A Nielsen Finn C FC Bonven Bjarne B Egebjerg Jan J
RNA (New York, N.Y.) 20060508 7
Members of the family of adenosine deaminases acting on RNA (ADARs) can catalyze the hydrolytic deamination of adenosine to inosine and thereby change the sequence of specific mRNAs with highly double-stranded structures. The ADARs all contain one or more repeats of the double-stranded RNA binding motif (DRBM). By both in vitro and in vivo assays, we show that the DRBMs of rat ADAR2 are necessary and sufficient for dimerization of the enzyme. Bioluminescence resonance energy transfer (BRET) demo ...[more]