Ontology highlight
ABSTRACT:
SUBMITTER: Milla CE
PROVIDER: S-EPMC4079258 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Milla Carlos E CE Chmiel James F JF Accurso Frank J FJ VanDevanter Donald R DR Konstan Michael W MW Yarranton Geoffrey G Geller David E DE
Pediatric pulmonology 20130909 7
Pseudomonas aeruginosa (Pa) airway infection is associated with increased morbidity and mortality in cystic fibrosis (CF). The type III secretion system is one of the factors responsible for the increased virulence and pro-inflammatory effects of Pa. KB001 is a PEGylated, recombinant, anti-Pseudomonas-PcrV antibody Fab' fragment that blocks the function of Pa TTSS. We studied the safety, pharmacokinetic (PK), and pharmacodynamic properties of KB001 in CF subjects with chronic Pa infection. Twent ...[more]