Ontology highlight
ABSTRACT:
SUBMITTER: Stout EP
PROVIDER: S-EPMC4079331 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Stout E Paige EP Choi Michael Y MY Castro Januario E JE Molinski Tadeusz F TF
Journal of medicinal chemistry 20140610 12
Chronic lymphocytic leukemia (CLL) is the most common lymphoid neoplasia in Western societies and is currently incurable. Multiple treatment options are practiced, but the available small molecule drugs suffer from dose-limiting toxicity and undesirable side effects. The need for new, less toxic treatments is a pressing concern. Here, we demonstrate that (-)-agelastatin A (1a), a pyrrole-imidazole alkaloid obtained from a marine sponge, exhibits potent in vitro activity against primary cell line ...[more]