Ontology highlight
ABSTRACT:
SUBMITTER: Mason JM
PROVIDER: S-EPMC4079730 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Mason Jennifer M JM Logan Hillary L HL Budke Brian B Wu Megan M Pawlowski Michal M Weichselbaum Ralph R RR Kozikowski Alan P AP Bishop Douglas K DK Connell Philip P PP
Cancer research 20140421 13
RAD51 is the central protein that catalyzes DNA repair via homologous recombination, a process that ensures genomic stability. RAD51 protein is commonly expressed at high levels in cancer cells relative to their noncancerous precursors. High levels of RAD51 expression can lead to the formation of genotoxic RAD51 protein complexes on undamaged chromatin. We developed a therapeutic approach that exploits this potentially toxic feature of malignancy, using compounds that stimulate the DNA-binding a ...[more]