Ontology highlight
ABSTRACT:
SUBMITTER: Bortolato A
PROVIDER: S-EPMC4080969 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Bortolato Andrea A Doré Andrew S AS Hollenstein Kaspar K Tehan Benjamin G BG Mason Jonathan S JS Marshall Fiona H FH
British journal of pharmacology 20140701 13
Class B GPCRs of the secretin family are important drug targets in many human diseases including diabetes, neurodegeneration, cardiovascular disease and psychiatric disorders. X-ray crystal structures for the glucagon receptor and corticotropin-releasing factor receptor 1 have now been published. In this review, we analyse the new structures and how they compare with each other and with Class A and F receptors. We also consider the differences in druggability and possible similarity in the activ ...[more]