Ontology highlight
ABSTRACT:
SUBMITTER: Chun L
PROVIDER: S-EPMC4077135 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Acta pharmacologica Sinica 20120130 3
The G-protein-coupled receptors (GPCRs) are one of the largest super families of cell-surface receptors and play crucial roles in virtually every organ system. One particular family of GPCRs, the class C GPCRs, is distinguished by a characteristically large extracellular domain and constitutive dimerization. The structure and activation mechanism of this family result in potentially unique ligand recognition sites, thereby offering a variety of possibilities by which receptor activity might be m ...[more]