Ontology highlight
ABSTRACT:
SUBMITTER: Lesma G
PROVIDER: S-EPMC4081462 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Molecular diversity 20140206 2
A representative series of structural analogs of the antimitotic tripeptides hemiasterlins have been designed and synthesized, as potential inhibitors of tubulin polymerization. Relying also on a computational approach, we aimed to explore unknown extensive changes at the C-fragment, by incorporating the conformationally required double bond into five- and six-membered rings. Key steps of the synthetic strategy are a dynamic resolution affording the A-fragment in 97 % ee and the preparation of s ...[more]