Ontology highlight
ABSTRACT:
SUBMITTER: Owen B
PROVIDER: S-EPMC9400386 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Owen Benjamin B de Gaetano Monica M Gaffney Andrew A Godson Catherine C Guiry Patrick J PJ
Organic letters 20220808 32
Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmetric synthesis of four BCP-containing synthetic lipoxin A<sub>4</sub> mimetics (BCP-sLXms) in which the key steps were a Suzuki coupling, an asymmetric ketone reduction, and a triethylborane-initiated radical bicyclopentylation. These mimetics were sc ...[more]