Ontology highlight
ABSTRACT:
SUBMITTER: Spyridaki K
PROVIDER: S-EPMC4081936 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Spyridaki Katerina K Matsoukas Minos-Timotheos MT Cordomi Arnau A Gkountelias Kostas K Papadokostaki Maria M Mavromoustakos Thomas T Logothetis Diomedes E DE Margioris Andrew N AN Pardo Leonardo L Liapakis George G
The Journal of biological chemistry 20140516 27
The corticotropin-releasing factor (CRF) type 1 receptor (CRF1R) for the 41-amino acid peptide CRF is a class B G protein-coupled receptor, which plays a key role in the response of our body to stressful stimuli and the maintenance of homeostasis by regulating neural and endocrine functions. CRF and related peptides, such as sauvagine, bind to the extracellular regions of CRF1R and activate the receptor. In contrast, small nonpeptide antagonists, which are effective against stress-related disord ...[more]