Ontology highlight
ABSTRACT:
SUBMITTER: Haile ST
PROVIDER: S-EPMC4082431 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Haile Samuel T ST Horn Lucas A LA Ostrand-Rosenberg Suzanne S
Cancer immunology research 20140402 7
Tumor cells use various methods of immunosuppression to overcome antitumor immunity. One such method is that of programmed death ligand-1 (PD-L1 or B7-H1), which upon binding its receptor PD-1 on T cells triggers apoptotic death of the activated T cells. Overexpression of the costimulatory molecule CD80 on PD-L1(+) tumor cells, or inclusion of a soluble form of CD80 (CD80-Fc), maintains the activation of PD-1(+)-activated T cells. Using T cells from CD28-deficient mice and antibodies to block CD ...[more]