Ontology highlight
ABSTRACT:
SUBMITTER: Kamata T
PROVIDER: S-EPMC5099366 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kamata Toshiko T Suzuki Akane A Mise Naoko N Ihara Fumie F Takami Mariko M Makita Yuji Y Horinaka Atsushi A Harada Kazuaki K Kunii Naoki N Yoshida Shigetoshi S Yoshino Ichiro I Nakayama Toshinori T Motohashi Shinichiro S
Cancer immunology, immunotherapy : CII 20160915 12
The role of invariant natural killer T (iNKT) cells in antitumor immunity has been studied extensively, and clinical trials in patients with advanced cancer have revealed a prolonged survival in some cases. In recent years, humanized blocking antibodies against co-stimulatory molecules such as PD-1 have been developed. The enhancement of T cell function is reported to improve antitumor immunity, leading to positive clinical effects. However, there are limited data on the role of PD-1/programmed ...[more]