Ontology highlight
ABSTRACT:
SUBMITTER: Barile E
PROVIDER: S-EPMC4082471 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
ChemMedChem 20140326 7
Because of its overexpression in a range of solid tumors, the EphA2 receptor is a validated target for cancer therapeutics. We recently described a new targeted delivery system based on specific EphA2-targeting peptides conjugated with the chemotherapeutic agent paclitaxel. Here, we investigate the chemical determinants responsible for the stability and degradation of these agents in plasma. Introducing modifications in both the peptide and the linker between the peptide and paclitaxel resulted ...[more]