Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3537892 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20121115 1
<h4>Purpose</h4>YSA is an EphA2-targeting peptide that effectively delivers anticancer agents to prostate cancer tumors. Here, we report on how we increased the drug-like properties of this delivery system.<h4>Experimental design</h4>By introducing non-natural amino acids, we have designed two new EphA2 targeting peptides: YNH, where norleucine and homoserine replace the two methionine residues of YSA, and dYNH, where a D-tyrosine replaces the L-tyrosine at the first position of the YNH peptide. ...[more]