Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity.
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ABSTRACT:
SUBMITTER: Lehmann-Horn K
PROVIDER: S-EPMC4184778 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
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Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity.
Lehmann-Horn Klaus K Kinzel Silke S Feldmann Linda L Radelfahr Florentine F Hemmer Bernhard B Traffehn Sarah S Bernard Claude C A CC Stadelmann Christine C Brück Wolfgang W Weber Martin S MS
Annals of clinical and translational neurology 20140703 7
Clinical trials revealed that systemic administration of B-cell-depleting anti-CD20 antibodies can hold lesion formation in the early relapsing-remitting phase of multiple sclerosis (MS). Throughout the secondary-progressive (SP) course of MS, pathogenic B cells may, however, progressively replicate within the central nervous system (CNS) itself, which is largely inaccessible to systemic anti-CD20 treatment. Utilizing the murine MS model of experimental autoimmune encephalomyelitis, we show that ...[more]
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