Ontology highlight
ABSTRACT:
SUBMITTER: Pezic D
PROVIDER: S-EPMC4083086 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Pezic Dubravka D Manakov Sergei A SA Sachidanandam Ravi R Aravin Alexei A AA
Genes & development 20140617 13
Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. In mice, piRNA-guided transposon repression correlates with establishment of CpG DNA methylation on their sequences, yet the mech ...[more]