Geometric analysis of alloreactive HLA ?-helices.
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ABSTRACT:
SUBMITTER: Ribarics R
PROVIDER: S-EPMC4083606 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Geometric analysis of alloreactive HLA α-helices.
Ribarics Reiner R Karch Rudolf R Ilieva Nevena N Schreiner Wolfgang W
BioMed research international 20140617
Molecular dynamics (MD) is a valuable tool for the investigation of functional elements in biomolecules, providing information on dynamic properties and processes. Previous work by our group has characterized static geometric properties of the two MHC α-helices comprising the peptide binding region recognized by T cells. We build upon this work and used several spline models to approximate the overall shape of MHC α-helices. We applied this technique to a series of MD simulations of alloreactive ...[more]
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