Ontology highlight
ABSTRACT:
SUBMITTER: Moshfegh Y
PROVIDER: S-EPMC4083618 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nature cell biology 20140525 6
Rho family GTPases control cell migration and participate in the regulation of cancer metastasis. Invadopodia, associated with invasive tumour cells, are crucial for cellular invasion and metastasis. To study Rac1 GTPase in invadopodia dynamics, we developed a genetically encoded, single-chain Rac1 fluorescence resonance energy (FRET) transfer biosensor. The biosensor shows Rac1 activity exclusion from the core of invadopodia, and higher activity when invadopodia disappear, suggesting that reduc ...[more]