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Ugi 4-CR Synthesis of ?- and ?-Lactams providing new access to diverse enzyme interactions, a PDB analysis.

ABSTRACT: A three step synthesis of N-unsubstituted tetrazolo ?- and ?-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted ?- and ?-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.

SUBMITTER: Boltjes A

PROVIDER: S-EPMC4084911 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis.

Boltjes André A Liao George P GP Zhao Ting T Herdtweck Eberhardt E Dömling Alexander A

MedChemComm 20140701 7

A three step synthesis of <i>N</i>-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the <i>N</i>-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites. ...[more]

PMID: 25013719

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