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Various cyclization scaffolds by a truly Ugi 4-CR.

ABSTRACT: Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of ?-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.

SUBMITTER: Sinha MK

PROVIDER: S-EPMC3772509 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Various cyclization scaffolds by a truly Ugi 4-CR.

Sinha Mantosh K MK Khoury Kareem K Herdtweck Eberhardt E Dömling Alexander A

Organic & biomolecular chemistry 20130613 29

Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold. ...[more]

PMID: 23760036

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