Ontology highlight
ABSTRACT:
SUBMITTER: Hicks C
PROVIDER: S-EPMC4085106 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hicks Chindo C Koganti Tejaswi T Giri Shankar S Tekere Memory M Ramani Ritika R Sitthi-Amorn Jitsuda J Vijayakumar Srinivasan S
Biomarker insights 20140629
Genome-wide association studies (GWAS) have achieved great success in identifying single nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with risk of developing prostate cancer. However, GWAS do not typically link the genetic variants to the disease state or inform the broader context in which the genetic variants operate. Here, we present a novel integrative genomics approach that combines GWAS information with gene expression data to infer the causal associ ...[more]