Ontology highlight
ABSTRACT:
SUBMITTER: Tan KP
PROVIDER: S-EPMC4086094 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Tan Kuan Pern KP Khare Shruti S Varadarajan Raghavan R Madhusudhan Mallur Srivatsan MS
Nucleic acids research 20140429 Web Server issue
Temperature sensitive (Ts) mutants of proteins provide experimentalists with a powerful and reversible way of conditionally expressing genes. The technique has been widely used in determining the role of gene and gene products in several cellular processes. Traditionally, Ts mutants are generated by random mutagenesis and then selected though laborious large-scale screening. Our web server, TSpred (http://mspc.bii.a-star.edu.sg/TSpred/), now enables users to rationally design Ts mutants for thei ...[more]