Ontology highlight
ABSTRACT:
SUBMITTER: Palczewska G
PROVIDER: S-EPMC4087080 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nature medicine 20140622 7
Two-photon excitation microscopy can image retinal molecular processes in vivo. Intrinsically fluorescent retinyl esters in subcellular structures called retinosomes are an integral part of the visual chromophore regeneration pathway. Fluorescent condensation products of all-trans-retinal accumulate in the eye with age and are also associated with age-related macular degeneration (AMD). Here, we report repetitive, dynamic imaging of these compounds in live mice through the pupil of the eye. By l ...[more]