Ontology highlight
ABSTRACT:
SUBMITTER: Kanow MA
PROVIDER: S-EPMC5617631 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kanow Mark A MA Giarmarco Michelle M MM Jankowski Connor Sr CS Tsantilas Kristine K Engel Abbi L AL Du Jianhai J Linton Jonathan D JD Farnsworth Christopher C CC Sloat Stephanie R SR Rountree Austin A Sweet Ian R IR Lindsay Ken J KJ Parker Edward D ED Brockerhoff Susan E SE Sadilek Martin M Chao Jennifer R JR Hurley James B JB
eLife 20170913
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as f ...[more]