Ontology highlight
ABSTRACT:
SUBMITTER: Katewa SD
PROVIDER: S-EPMC4715572 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cell metabolism 20151125 1
Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that the core circadian clock genes, timeless (tim) and period (per), are required for the metabolic and lifespan responses to DR in Drosophila. Consistent with the involvement of a circadian mechanism, DR enhances the amplitude of cycling of most circadian clock genes, including ti ...[more]