NMR structures of ?-proteobacterial ATPase-regulating ?-subunits.
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ABSTRACT:
SUBMITTER: Serrano P
PROVIDER: S-EPMC4089900 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
NMR structures of α-proteobacterial ATPase-regulating ζ-subunits.
Serrano Pedro P Geralt Michael M Mohanty Biswaranjan B Wüthrich Kurt K
Journal of molecular biology 20140513 14
NMR structures of ζ-subunits, which are recently discovered α-proteobacterial F1F0-ATPase-regulatory proteins representing a Pfam protein family of 246 sequences from 219 species (PF07345), exhibit a four-helix bundle, which is different from all other known F1F0-ATPase inhibitors. Chemical shift mapping reveals a conserved ADP/ATP binding site in ζ-subunit, which mediates long-range conformational changes related to function, as revealed by the structure of the Paracoccus denitrificans ζ-subuni ...[more]
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