Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC4090504 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Jin Lu L Ye Fei F Zhao Dan D Chen Shijie S Zhu Kongkai K Zheng Mingyue M Jiang Ren-Wang RW Jiang Hualiang H Luo Cheng C
BioMed research international 20140619
DNA methyltransferases play crucial roles in establishing and maintenance of DNA methylation, which is an important epigenetic mark. Flipping the target cytosine out of the DNA helical stack and into the active site of protein provides DNA methyltransferases with an opportunity to access and modify the genetic information hidden in DNA. To investigate the conversion process of base flipping in the HhaI methyltransferase (M.HhaI), we performed different molecular simulation approaches on M.HhaI-D ...[more]